Health & Medical intensive care

Albumin Supplementation in Sepsis Patients

´╗┐Albumin Supplementation in Sepsis Patients


A growing body of literature suggests that hydroxyethyl starch solutions may cause renal damage, particularly in patients with sepsis. Conversely, albumin has been suggested to confer benefit in sepsis resuscitation.

In this study, albumin supplementation to maintain normal circulating serum albumin levels was not shown to be superior overall to crystalloid administration alone. This was true for starting the intervention earlier or later (< 6 hours vs 6-24 hours), and for outcomes measured earlier or later. But the subset of patients with septic shock did have statistically greater survival at 90 days, which raises the question of albumin superiority for this subgroup, and perhaps even as a later effect not related to the early resuscitation.

Unfortunately, for general patient care, this study does not provide a definite answer. And the major question of whether different uses of albumin, such as in the earliest phases of fluid resuscitation and targeted to goals other than maintaining circulating level, still needs to be studied.

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