Ask the Experts - Role of Rh Antigens in Renal Transplantation?
We want to do a renal transplant in which the living-related donor's (sister) blood group is O Rh+ and the recipient's blood group is O Rh- (male). ABO blood groups are compatible. Should we go ahead for tissue typing and lymphocyte crossmatch?
Safrad Sial, MD
This is conventionally not considered to be a problem. Rh antigens are not expressed on endothelial tissue and, therefore, play no apparent role in graft rejection or survival. In other words, an organ from a donor with ABO type O+ can be safely transplanted into an ABO type O- recipient. As long as the lymphocyte crossmatch is negative, the transplant can go forward.