Health & Medical Allergies & Asthma

Susceptibility Genes for Allergic Rhinitis and Allergy

´╗┐Susceptibility Genes for Allergic Rhinitis and Allergy

Abstract and Introduction

Abstract


Purpose of review Allergic rhinitis and allergy are complex conditions, in which both genetic and environmental factors contribute to the pathogenesis. Genome-wide association studies (GWASs) employing common single-nucleotide polymorphisms have accelerated the search for novel and interesting genes, and also confirmed the role of some previously described genes which may be involved in the cause of allergic rhinitis and allergy. The aim of this review is to provide an overview of the genetic basis of allergic rhinitis and the associated allergic phenotypes, with particular focus on GWASs.

Recent findings The last decade has been marked by the publication of more than 20 GWASs of allergic rhinitis and the associated allergic phenotypes. Allergic diseases and traits have been shown to share a large number of genetic susceptibility loci, of which IL33/IL1RL1, IL-13-RAD50 and C11orf30/LRRC32 appear to be important for more than two allergic phenotypes. GWASs have further reflected the genetic heterogeneity underlying allergic phenotypes.

Summary Large-scale genome-wide association strategies are underway to discover new susceptibility variants for allergic rhinitis and allergic phenotypes. Characterization of the underlying genetics provides us with an insight into the potential targets for future studies and the corresponding interventions.

Introduction


Allergic rhinitis is an allergen-specific immunoglobulin E (IgE)-mediated inflammatory disease of the nasal mucosa, characterized by sneezing, nasal itching, rhinorrhoea and nasal congestion. The prevalence of allergic rhinitis is high globally, including China, and increasing progressively. Although not a life-threatening disorder, allergic rhinitis adversely impacts the quality of life of the affected individuals, and imposes a socioeconomic burden on both the individual and the society alike.

Allergic rhinitis and allergy are complex conditions, in which interaction between genetic and environmental factors contribute to the pathogenesis of these conditions. Family linkage and candidate-gene studies based on the positional cloning have demonstrated that a number of susceptibility genes, including immune relevant factors and regulators of the epithelial barrier, play a part in the cause of allergic rhinitis and allergy phenotypes. However, the findings from these studies are neither consistent nor conclusive, because of the genetic heterogeneity. The elucidation of the human genome has enabled the study of genomic variation amongst individuals with specific conditions and led to the development of genome-wide association studies (GWASs) employing common single-nucleotide polymorphisms (SNPs). The GWASs have thus both accelerated the search for novel and interesting genes, and confirmed the role of some previously described genes associated with the development of allergic rhinitis and allergy. The aim of this study is to review the current literature and provide an overview of the genetic basis of allergic rhinitis and other allergic phenotypes in relation to allergic rhinitis, with particular focus on GWASs.

You might also like on "Health & Medical"

#

Wood Burning Stove & Allergies

#

Attack Against Allergy Mold

#

Skin Allergies

#

Live the Rural Life, Avoid Asthma?

#

Do You Have A Dog Allergy?

#

Cat Allergy in Babies

#

General Information About Allergies

#

Rhinitis and its Impact on Work

Leave a reply