Health & Medical Menopause health

Progression to At-risk Obesity in Perimenopausal Women

Progression to At-risk Obesity in Perimenopausal Women


Khan UI, Wang D, Karvonen-Gutierrez CA, Khalil N, Ylitalo KR, Santoro N. Progression from metabolically benign to at-risk obesity in perimenopausal women: a longitudinal analysis of Study of Women Across the Nation (SWAN). J Clin Endocrinol Metab. 2014; 99(7):2516-2525.

Researchers examined women’s progression from a metabolically benign overweight/obese to an at-risk overweight/obese phenotype and factors associated with that progression over 7 years using discrete-time proportional hazard modeling on data from the Study of Women’s Health Across the Nation (SWAN). Of 866 metabolically benign overweight/obese phenotypes at baseline, 43% progressed to an at-risk phenotype—they had higher baseline body mass index (BMI) and a higher prevalence of cardiometabolic abnormalities, including elevated glucose, triglycerides, and blood pressure and low high-density lipoprotein cholesterol. Baseline impaired fasting glucose showed the strongest association with risk of progression, and physical activity played a protective role in decreasing risk of progression.

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